Simvastatin was most commonly prescribed and simvastatin drug coprescription predominated, especially at discharge. This study is created by ehealthme based on reports of 7,286 people who take levothyroxine sodium and simvastatin from the food and drug administration fda, and is updated regularly. Zocor simvastatin dose, indications, adverse effects. Mark this risk when a client is taking a drug or medication that can interfere with nutrient intake or use. There are 496 drug interactions with zocor simvastatin zocor simvastatin disease interactions. Vitamin d and simvastatin drug interactions ehealthme. If, however, a patient who is currently tolerating the 80mg dose of zocor needs to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin, that patient should be switched to an alternative statin with less potential for the drug drug interaction. There is no evidence of significant interaction when amlodipine is coadministered with atorvastatin, pitavastatin, rosuvastatin, fluvastatin, and pravastatin, and combination therapy may be considered. Oct 17, 2010 the effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking drug drug interaction, food, beverages, dietary supplements the person is consuming drug nutrient food interaction or another disease the person has drug disease interaction.
This interaction will lead to increased drug levels in the blood enhancing. Jan 02, 2017 a 2015 study examined a group of individuals that were considered statin intolerant, meaning that they suffered from statin side effects, particularly muscle pains, that made it difficult or unbearable to continue taking the drug. Simvastatin interaction with food, herbs and alcohol it is important to know how to take the medication to avoid the drug food interaction. Impact of food on effectiveness of a drug a medication has ingredients, just as food does, that allow it to function correctly when taken in order to help the body in some way. Simvastatin is used along with a proper diet to help lower bad cholesterol and fats such as ldl, triglycerides and raise good cholesterol hdl in the blood. Nearly a quarter of all adults over age 40 take medication to treat high cholesterol, and most often, its a statin drug. Doses of simvastatin 10 mgd and doses of lovastatin 20 mgd when used with diltiazem or verapamil are not recommended. Drug interactions with simvastatin drugs home page. Simvastatin and ibuprofen drug interactions a study of. Drug nutrient interactions table of common drugs and medications. Paritaprevir in fixeddose combination is predicted to increase the risk of rhabdomyolysis when given with simvastatin. Some side effects may occur that usually do not need medical.
Drug interactions of medications commonly used in diabetes. Simvastatin is a, fda approved prescription medication that is used along with a proper diet to help lower bad cholesterol and fats such as ldl, triglycerides and raise good cholesterol in the blood. Statins may, for example, raise blood levels of the clotpreventing drug warfarin, which could increase the risk of internal bleeding. Eclectic medical publications, druginduced nutrient depletion handbook. Mar 31, 2014 simvastatin was most commonly prescribed and simvastatin drug coprescription predominated, especially at discharge. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug. Ezetimibesimvastatin and alcohol food interactions. Some medicines should not be taken with simvastatin.
Dec 11, 2014 many important interactions for simvastatin zocor and atorvastatin relate to drugs that inhibit or induce metabolism via the cytochrome p450 cyp3a4 enzyme, or that affect transport proteins. Give your doctor an uptodate list of all the medicines you take, including overthecounter medicines, herbal products, vitamins, and supplements. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. This is a general list of medical conditions and medications that you should be aware of. Grapefruit interferes with your bodys metabolism of atorvastatin lipitor, simvastatin zocor and lovastatin altoprev, mevacor, so your intended dose might not be accurate. Zocor simvastatin side effects, dosage, interactions. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. If you are at high risk of heart disease, the starting dose is. The true incidence of drug interactions is unknown because many are not reported, do not result in significant harm to patients, or do not require admission to a hospital. Food medication interactions 19th edition zaneta m pronsky ms rd ldn fada, dean elbe bsc pharm bcpp pharm d, laura finn bcgp fascp, william roberts md phd, keith ayoob edd rd fada, sol epstein md frcp facp on. Niacin simvastatin interactions grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Prima health, herb contraindications and drug interac tions.
Handbook of fooddrug interactions nutrition assessment. This study is created by ehealthme based on reports of 20 people who take simvastatin and cannabis from food and drug administration fda, and is updated regularly. Drugs can influence food intake, nutrient digestion, absorption, distribution, metabolism to active forms, function, catabolism and excretion 5, 6. Statins can lower heart disease risk dramatically, but certain cautions apply. There are 6 disease interactions with zocor simvastatin which include. Given interaction potential between simvastatin and protease inhibitors, consider avoiding efavirenz and simvastatin in case patients antiretroviral regimen is changed and simvastatin is not changed to another statin. Broadway books, az guide to drugherbvitamin interactions. A food drug interaction may prevent a medicine form working the way it should, cause a side effect from a medicine to get worse or better. In these cases, your doctor may want to change the dose, or other precautions may be necessary.
Table 1 summarizes several possible interactions of drugs with. Dec 11, 2014 the maximum recommended dose for simvastatin in conjunction with amlodipine or diltiazem is now 20 mgday a full updated listing of all the interactions is provided in the table below. Aha statement on drugdrug interactions with statins. The exposure to all potential statin drug interactions was similar at hospital admission 26. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Az guide to drugherbvitamin interactions revised and. In june 2011, the fda placed new labeling restrictions on simvastatin. Usually, the starting dose is 10 or 20 mg once a day, in the evening. We look into the drug interactions by gender and age. Atorvastatin interacts with grapefruit and its juice. Drug interactions are reported among people who take levothyroxine sodium and simvastatin together.
There is 1 alcoholfoodlifestyle interaction with simvastatin. Once absorbed into the portal venous system, while all statins. Food drug interactions is a broader term that describes the effects of a drug on nutritional status. Interactions between antihypertensive drugs and food. Research has found that statin drugs can deplete the body of coenzyme q10, vitamin d and vitamin k2, which may contribute to statins common side effects. Adverse drug reactions and medication errors are all potential consequences of polypharmacy. If you are taking drugs, you may need to avoid certain foods. For example, taking alcohol with the antibiotic metronidazole can cause flushing, headache, palpitations, and nausea and vomiting. This study is created by ehealthme based on reports of 7,009 people who take vitamin d and simvastatin from the food and drug administration fda, and is updated regularly.
Drug nutrient interactions are defined as physical, chemical, physiologic, or pathophysiologic relationships between a drug and a nutrient, and typically involve multiple factors 3,4. Although many people do not consider alcohol a nutrient, it affects body processes and interacts with many drugs. The changes recommended against using 80mg doses of simvastatin, added 4 drugs to the list of contraindicated agents, and included several new simvastatin dose limitations when prescribed with drugs that inhibit its elimination. Ask your doctor to check for potential interactions that simvastatin may have with any other medicines you take. Simvastatin oral tablet is available as the brandname drug zocor. Fooddrug interactions what you eat and drink can affect the way your medicines work. Food and drug administration fda is notifying the public that it has revised the dose limitation for the cholesterollowering drug simvastatin. Drug interactions are reported among people who take vitamin d and simvastatin together. As shown in tables 3 and 4 and as discussed below, we have surveyed the literature to identify reports suggesting important food and phytochemical modulation of drug metabolizing enzymes and drug transporters leading to potential important nutrient drug interactions. This table lists common drugs that can affect nutrition status. A clinicians guide to statin drugdrug interactions. See what the interactions are and for which people.
In some cases, simvastatin drug interactions can cause your body to metabolize the medicines differently than intended, which can increase your risk of developing serious muscle problems, including myopathy and rhabdomyolysis. It is important to know if you need to avoid any food, herbs, or alcohol when taking simvastatin. Eating grapefruit can inhibit cytochrome p450 34a, slowing metabolism of some drugs eg, amiodarone. Atorvastatin interaction with food, herbs and alcohol. Food and drug administration fda is recommending limiting the use of the highest approved dose of the cholesterollowering medication, simvastatin 80. Niacin, warfarin, and fibrates are among the drugs that can potentially interact with simvastatin. Simvastatin and ranexa drug interactions ehealthme. Drug interactions are reported among people who take simvastatin and cannabis together. Handbook of drug nutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drug nutrition interactions which will act as a reliable reference for clinicians and students for many years to come. From the experts at healthnotes, this revised and updated edition contains the newest information on thousands of drugs and supplements, based on studies published in the leading medical journals. When the way a medicine works is affected by food and drinks this is called a fooddrug interaction.
Grapefruit juice can significantly increase the blood levels of simvastatin. Simvastatin interaction with food, herbs and alcohol. Common side effects are muscle pain, leg pain, vomiting, and stomach cramps. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal. Always read the package insert to identify the drug interactions specific to the statin you are taking, whether it is crestor rosuvastatin, lescol fluvastatin, lipitor atorvastatin, mevacor lovastatin, pravachol pravastatin, or zocor simvastatin. Niacinsimvastatin side effects, dosage, interactions. Simvastatin interactions bnf content published by nice. Zocor tablets come in 5 milligrams mg, 10, 20, 40 and 80 mg.
If the client is taking a drug or medication that isnt on this list, check the food medications interactions book for possible side effects. Simvastatin oral interactions with other medication. This emedtv page explains how drug interactions with simvastatin can raise your risk of serious muscle problems such as myopathy, among other things. Learn about drug interactions between atorvastatin oral and simvastatin oral and use the rxlist drug interaction checker to check drug combinations. Drug interactions are reported among people who take simvastatin and ranexa together. Drug interactions drugs merck manuals consumer version. This study is created by ehealthme based on reports of 652 people who take simvastatin and ranexa from the food and drug administration fda, and is updated regularly. Handbook of drugnutrient interactions nutrition and. Coadministration with grapefruit juice may significantly increase the plasma concentrations of lovastatin and simvastatin and their active acid metabolites. In case of overdose, get medical help or contact a poison control center immediately. Jun 30, 2015 a half grapefruit is a great way to start the day unless youre taking a cholesterollowering statin such as atorvastatin lipitor or simvastatin zocor. Examples of statins available include atorvastatin lipitor, fluvastatin lescol, lovastatin mevacor, altocor, pravastatin pravachol, pitavastatin livalo, simvastatin zocor, and rosuvastatin crestor. Here, consumer reports lists food and drug interactions that you need to know about to stay safe. Statins are a class of drug prescribed for reducing blood cholesterol levels in individuals with high cholesterol.
Look up a drug to see which other drugs it interacts with and how serious those interactions are. Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary. The book starts the reader out with some basic concepts of pharmacy, moves on through drug biopharmaceutics, food drug interactions and metabolism. Do not take zocor if you are allergic to simvastatin or any ingredients contained in this drug. Nutrientdrug interactions nutritional disorders merck. Zocor simvastatin tablets food and drug administration. Foods can enhance, delay, or decrease drug absorption. Levothyroxine sodium and simvastatin drug interactions. A new book from aarp offers dietary guidance on food drug interactions. A few of the drugs that can potentially interact with simvastatin include gemfibrozil, danazol, amiodarone, and digoxin. Use of prescription or overthecounter drugs or medications shown to interfere with nutrient intake or use, to an extent that nutritional status is compromised. Each of these interactions may lead to many complications. Do not drink more than 1 quart of grapefruit juice daily.
There is 1 alcoholfood lifestyle interaction with ezetimibe simvastatin. There are 6 disease interactions with simvastatin which include. Simvastatin should not be taken by people taking the medicines gemfibrozil, ciclosporin, danazol, idelalisib or nefazadone. Drug interactions can be caused by prescription and overthecounter medications, herbal products or vitamins, foods, diseases, and genetics family history. Simvastatin 80 mg is restricted to patients who have been taking simvastatin 80 mg chronically for example. The az guide to drug herbvitamin interactions is an essential resource to understanding the interactions that may affect your health. Simvastatin and cannabis drug interactions a study of fda. The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking drug drug interaction, food, beverages, dietary supplements the person is consuming drug nutrient food interaction or another disease the person has drug disease interaction.
Drug and food interactions, effectiveness, and the safety of statins are provided. Drug nutrient interactions involve changes to a drug caused by a nutrient, or changes to a nutrient as a result of the drug. Doctors or pharmacists can answer questions about possible alcohol and drug interactions. Statins are medications that work by reducing the amount of cholesterol made by the liver. Simvastatin is fdaapproved for the treatment of heterozygous familial hypercholesterolemia and is recommended for hyperlipidemia when either. Provides a summary of interactions with vitamins, herbs, and food. Approximately 22 million prescriptions are written in canada each year for statin drugs let that sink in for a minute.
This study is created by ehealthme based on reports of 5,187 people who take simvastatin and ibuprofen from food and drug administration fda, and is updated regularly. Drug interaction with any of these substances may enhance or decrease the effect of simvastatin. Interactions between simvastatin oral and avoidgrapefruit. Rosuvastatin, pitavastatin, and simvastatin are not affected by food, whereas.
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